The two main tourist areas of the city are in Fisherman's wharf, and Union Square, and there are many hotels in these areas to satisfy all budgets and needs, whether you are looking for somewhere basic to act as a base for exploring the city, or a luxurious hotel with every conceivable facility to relax in.
The 3* Ramada Mark Twain at Union Square is an excellent budget choice that offers a good standard of accommodation in a good location.
In Fisherman's Wharf, the 4* Sheraton Hotel is close top the pier 39 ferry to Alcatraz and the hotel has a wide range of excellent facilities as well as a high standard of Service.
For the personal service that you only get in a boutique hotel, the 5* Argonaut, also in Fisherman's Wharf has a nautical theme and is located directly above the San Francisco Maritime Museum.
If you want the best service and facilities that the city has to offer, then look no further than the Stunning Hotel Monaco in the middle of the city is convenient for the main attractions as well as having an excellent and luxurious health club and spa.